Results about the Gastrointestinal Tract and Other Clean Muscle Codeine leads to a discount in motility connected with an increase in sleek muscle tone within the antrum of the abdomen and duodenum. Digestion of food stuff while in the small intestine is delayed and propulsive contractions are lowered.
For nausea and vomiting in young children, the standard dose is 0.5 mg for each pound of overall body pounds, as well as the dose need to be adjusted for the age and bodyweight with the client as well as severity in the problem currently being handled.
patients who're allergic to promethazine, any in the elements in promethazine, or to other phenothiazines
The diagnostic evaluation of people with this syndrome is complicated. In arriving at a prognosis, it can be crucial to establish conditions where the clinical presentation contains equally really serious healthcare ailment (e.
Postmarketing scenarios of respiratory despair, which includes fatalities are claimed with utilization of promethazine in pediatric people.
Extended-expression animal research have not been executed to evaluate the carcinogenic probable of promethazine, nor are there other animal or human facts relating to carginogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic while in the Salmonella check system of Ames.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Answer really should not be enhanced if cough fails to respond; an unresponsive cough need to be reevaluated in 5 times or quicker for possible fundamental pathology, like foreign physique or reduced respiratory tract illness [see Dosage and Administration (two.three)].
Promethazine HCl Oral Option ought to be utilised cautiously in folks with heart problems or with impairment of liver read more perform.
Caution really should be exercised when administering Promethazine to pediatric people two years of age and more mature. It is recommended that the lowest efficient dose of Promethazine be used in pediatric individuals 2 a long time of age and older and concomitant administration of other medicines with respiratory depressant results be avoided.
It's soluble in drinking water and freely soluble in alcohol. It has a molecular body weight of 320.88, a molecular formulation of C17H20N2S•HCl, and the next structural formula:
Thing to consider should be specified on the discontinuation of Promethazine HCl and to using other medication if these reactions take place. Respiratory despair, nightmares, delirium, and agitated actions have also been reported in A few of these patients.
The diagnostic analysis of people with this syndrome is difficult. In arriving in a prognosis, it is crucial to recognize scenarios where the scientific presentation involves each major health care illness (e.
Promethazine HCl Oral Option should be utilized in the course of pregnancy only if the likely gain justifies the probable hazard into the fetus.
The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Resolution may perhaps improve the frequency of seizures in sufferers with seizure Issues, and could boost the possibility of seizures developing in other scientific configurations associated with seizures.